Gender differences in HIV-positive persons in use of cardiovascular disease-related interventions: D:A:D study
Identifieur interne : 003925 ( Main/Exploration ); précédent : 003924; suivant : 003926Gender differences in HIV-positive persons in use of cardiovascular disease-related interventions: D:A:D study
Auteurs : Camilla Ingrid Hatleberg [Danemark] ; Lene Ryom [Danemark] ; Wafaa El-Sadr [États-Unis] ; Amanda Mocroft [Royaume-Uni] ; Peter Reiss [Pays-Bas] ; Stephan De Wit [Belgique] ; Francois Dabis [France] ; Christian Pradier [France] ; Antonella D'Arminio Monforte [Italie] ; Martin Rickenbach [Suisse] ; Matthew Law [Australie] ; Jens Lundgren [Danemark] ; Caroline Sabin [Royaume-Uni]Source :
- Journal of the International AIDS Society [ 1758-2652 ] ; 2014.
Abstract
There is a lack of data on potential gender differences in the use of interventions to prevent and treat cardiovascular disease (CVD) in HIV-positive individuals. We investigated whether such differences exist in the D:A:D study.
Follow-up was from 01/02/99 until the earliest of death, 6 months after last visit or 01/02/13. Rates of initiation of lipid-lowering drugs (LLDs), angiotensin-converting enzyme inhibitors (ACEIs), anti-hypertensives and receipt of invasive cardiovascular procedures (ICPs; bypass, angioplasty, endarterectomy) were calculated in those without a myocardial infarction (MI) or stroke at baseline, overall and in groups known to be at higher CVD risk: (i) age >50, (ii) total cholesterol >6.2 mmol/l, (iii) triglyceride >2.3 mmol/l, (iv) hypertension, (v) previous MI, (vi) diabetes, or (vii) predicted 10-year CVD risk >10%. Poisson regression was used to assess whether rates of initiation were higher in men than women, after adjustment for these factors.
At enrolment, women (
Use of most CVD interventions was lower among women than men in the D:A:D study. Our findings suggest that actions should be taken to ensure that both men and women are monitored for CVD and, if eligible, receive appropriate CVD interventions.
Url:
DOI: 10.7448/IAS.17.4.19516
PubMed: 25394025
PubMed Central: 4224835
Affiliations:
- Australie, Belgique, Danemark, France, Italie, Pays-Bas, Royaume-Uni, Suisse, États-Unis
- Angleterre, Aquitaine, Canton de Vaud, Grand Londres, Hollande-Septentrionale, Hovedstaden, Lombardie, Nouvelle-Aquitaine, Nouvelle-Galles du Sud, Provence-Alpes-Côte d'Azur, Région de Bruxelles-Capitale, État de New York
- Amsterdam, Bordeaux, Bruxelles, Copenhague, Lausanne, Londres, Milan, New York, Nice, Sydney
- University College de Londres, Université Columbia, Université d'Amsterdam
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 001176
- to stream Pmc, to step Curation: 001037
- to stream Pmc, to step Checkpoint: 001576
- to stream PubMed, to step Corpus: 003278
- to stream PubMed, to step Curation: 003168
- to stream PubMed, to step Checkpoint: 003168
- to stream Ncbi, to step Merge: 001F88
- to stream Ncbi, to step Curation: 001F88
- to stream Ncbi, to step Checkpoint: 001F88
- to stream Main, to step Merge: 003961
- to stream Main, to step Curation: 003925
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Gender differences in HIV-positive persons in use of cardiovascular disease-related interventions: D:A:D study</title>
<author><name sortKey="Hatleberg, Camilla Ingrid" sort="Hatleberg, Camilla Ingrid" uniqKey="Hatleberg C" first="Camilla Ingrid" last="Hatleberg">Camilla Ingrid Hatleberg</name>
<affiliation wicri:level="3"><nlm:aff id="AF0001_19516">CHIP Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>CHIP Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen</wicri:regionArea>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ryom, Lene" sort="Ryom, Lene" uniqKey="Ryom L" first="Lene" last="Ryom">Lene Ryom</name>
<affiliation wicri:level="3"><nlm:aff id="AF0001_19516">CHIP Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>CHIP Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen</wicri:regionArea>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="El Sadr, Wafaa" sort="El Sadr, Wafaa" uniqKey="El Sadr W" first="Wafaa" last="El-Sadr">Wafaa El-Sadr</name>
<affiliation wicri:level="4"><nlm:aff id="AF0002_19516">Mailman School of Public Health, Columbia University, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Mailman School of Public Health, Columbia University, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
</author>
<author><name sortKey="Mocroft, Amanda" sort="Mocroft, Amanda" uniqKey="Mocroft A" first="Amanda" last="Mocroft">Amanda Mocroft</name>
<affiliation wicri:level="4"><nlm:aff id="AF0003_19516">Research Department of Infection and Population Health, University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Research Department of Infection and Population Health, University College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author><name sortKey="Reiss, Peter" sort="Reiss, Peter" uniqKey="Reiss P" first="Peter" last="Reiss">Peter Reiss</name>
<affiliation wicri:level="4"><nlm:aff id="AF0004_19516">Amsterdam Medical Center, University of Amsterdam, Stichting HIV Monitoring, Amsterdam, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Amsterdam Medical Center, University of Amsterdam, Stichting HIV Monitoring, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
<settlement type="city">Amsterdam</settlement>
</placeName>
<orgName type="university">Université d'Amsterdam</orgName>
</affiliation>
</author>
<author><name sortKey="De Wit, Stephan" sort="De Wit, Stephan" uniqKey="De Wit S" first="Stephan" last="De Wit">Stephan De Wit</name>
<affiliation wicri:level="3"><nlm:aff id="AF0005_19516">CHU Saint-Pierre Hospital, Saint-Pierre Cohort, Brussels, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>CHU Saint-Pierre Hospital, Saint-Pierre Cohort, Brussels</wicri:regionArea>
<placeName><settlement type="city">Bruxelles</settlement>
<region nuts="2">Région de Bruxelles-Capitale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dabis, Francois" sort="Dabis, Francois" uniqKey="Dabis F" first="Francois" last="Dabis">Francois Dabis</name>
<affiliation wicri:level="3"><nlm:aff id="AF0006_19516">ISPED, Centre Inserm U897, University of Bordeaux, Bordeaux, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>ISPED, Centre Inserm U897, University of Bordeaux, Bordeaux</wicri:regionArea>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pradier, Christian" sort="Pradier, Christian" uniqKey="Pradier C" first="Christian" last="Pradier">Christian Pradier</name>
<affiliation wicri:level="3"><nlm:aff id="AF0007_19516">Department of Public Health, Nice University Hospital, Nice, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Public Health, Nice University Hospital, Nice</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Nice</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="D Arminio Monforte, Antonella" sort="D Arminio Monforte, Antonella" uniqKey="D Arminio Monforte A" first="Antonella" last="D'Arminio Monforte">Antonella D'Arminio Monforte</name>
<affiliation wicri:level="3"><nlm:aff id="AF0008_19516">Department of Health Sciences, San Paolo University Hospital, Infectious Diseases Unit, Milan, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Health Sciences, San Paolo University Hospital, Infectious Diseases Unit, Milan</wicri:regionArea>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rickenbach, Martin" sort="Rickenbach, Martin" uniqKey="Rickenbach M" first="Martin" last="Rickenbach">Martin Rickenbach</name>
<affiliation wicri:level="3"><nlm:aff id="AF0009_19516">Institute of Social and Preventive Medicine, University of Lausanne, Swiss Cohort Study, Lausanne, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Institute of Social and Preventive Medicine, University of Lausanne, Swiss Cohort Study, Lausanne</wicri:regionArea>
<placeName><settlement type="city">Lausanne</settlement>
<region nuts="3" type="region">Canton de Vaud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Law, Matthew" sort="Law, Matthew" uniqKey="Law M" first="Matthew" last="Law">Matthew Law</name>
<affiliation wicri:level="3"><nlm:aff id="AF0010_19516">The Kirby Institute, University of New South Wales, Sydney, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The Kirby Institute, University of New South Wales, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lundgren, Jens" sort="Lundgren, Jens" uniqKey="Lundgren J" first="Jens" last="Lundgren">Jens Lundgren</name>
<affiliation wicri:level="3"><nlm:aff id="AF0001_19516">CHIP Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>CHIP Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen</wicri:regionArea>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sabin, Caroline" sort="Sabin, Caroline" uniqKey="Sabin C" first="Caroline" last="Sabin">Caroline Sabin</name>
<affiliation wicri:level="4"><nlm:aff id="AF0003_19516">Research Department of Infection and Population Health, University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Research Department of Infection and Population Health, University College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">25394025</idno>
<idno type="pmc">4224835</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224835</idno>
<idno type="RBID">PMC:4224835</idno>
<idno type="doi">10.7448/IAS.17.4.19516</idno>
<date when="2014">2014</date>
<idno type="wicri:Area/Pmc/Corpus">001176</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001176</idno>
<idno type="wicri:Area/Pmc/Curation">001037</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001037</idno>
<idno type="wicri:Area/Pmc/Checkpoint">001576</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001576</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">003278</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003278</idno>
<idno type="wicri:Area/PubMed/Curation">003168</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003168</idno>
<idno type="wicri:Area/PubMed/Checkpoint">003168</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003168</idno>
<idno type="wicri:Area/Ncbi/Merge">001F88</idno>
<idno type="wicri:Area/Ncbi/Curation">001F88</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001F88</idno>
<idno type="wicri:Area/Main/Merge">003961</idno>
<idno type="wicri:Area/Main/Curation">003925</idno>
<idno type="wicri:Area/Main/Exploration">003925</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Gender differences in HIV-positive persons in use of cardiovascular disease-related interventions: D:A:D study</title>
<author><name sortKey="Hatleberg, Camilla Ingrid" sort="Hatleberg, Camilla Ingrid" uniqKey="Hatleberg C" first="Camilla Ingrid" last="Hatleberg">Camilla Ingrid Hatleberg</name>
<affiliation wicri:level="3"><nlm:aff id="AF0001_19516">CHIP Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>CHIP Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen</wicri:regionArea>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ryom, Lene" sort="Ryom, Lene" uniqKey="Ryom L" first="Lene" last="Ryom">Lene Ryom</name>
<affiliation wicri:level="3"><nlm:aff id="AF0001_19516">CHIP Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>CHIP Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen</wicri:regionArea>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="El Sadr, Wafaa" sort="El Sadr, Wafaa" uniqKey="El Sadr W" first="Wafaa" last="El-Sadr">Wafaa El-Sadr</name>
<affiliation wicri:level="4"><nlm:aff id="AF0002_19516">Mailman School of Public Health, Columbia University, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Mailman School of Public Health, Columbia University, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
</author>
<author><name sortKey="Mocroft, Amanda" sort="Mocroft, Amanda" uniqKey="Mocroft A" first="Amanda" last="Mocroft">Amanda Mocroft</name>
<affiliation wicri:level="4"><nlm:aff id="AF0003_19516">Research Department of Infection and Population Health, University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Research Department of Infection and Population Health, University College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author><name sortKey="Reiss, Peter" sort="Reiss, Peter" uniqKey="Reiss P" first="Peter" last="Reiss">Peter Reiss</name>
<affiliation wicri:level="4"><nlm:aff id="AF0004_19516">Amsterdam Medical Center, University of Amsterdam, Stichting HIV Monitoring, Amsterdam, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Amsterdam Medical Center, University of Amsterdam, Stichting HIV Monitoring, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
<settlement type="city">Amsterdam</settlement>
</placeName>
<orgName type="university">Université d'Amsterdam</orgName>
</affiliation>
</author>
<author><name sortKey="De Wit, Stephan" sort="De Wit, Stephan" uniqKey="De Wit S" first="Stephan" last="De Wit">Stephan De Wit</name>
<affiliation wicri:level="3"><nlm:aff id="AF0005_19516">CHU Saint-Pierre Hospital, Saint-Pierre Cohort, Brussels, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>CHU Saint-Pierre Hospital, Saint-Pierre Cohort, Brussels</wicri:regionArea>
<placeName><settlement type="city">Bruxelles</settlement>
<region nuts="2">Région de Bruxelles-Capitale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dabis, Francois" sort="Dabis, Francois" uniqKey="Dabis F" first="Francois" last="Dabis">Francois Dabis</name>
<affiliation wicri:level="3"><nlm:aff id="AF0006_19516">ISPED, Centre Inserm U897, University of Bordeaux, Bordeaux, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>ISPED, Centre Inserm U897, University of Bordeaux, Bordeaux</wicri:regionArea>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pradier, Christian" sort="Pradier, Christian" uniqKey="Pradier C" first="Christian" last="Pradier">Christian Pradier</name>
<affiliation wicri:level="3"><nlm:aff id="AF0007_19516">Department of Public Health, Nice University Hospital, Nice, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Public Health, Nice University Hospital, Nice</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Nice</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="D Arminio Monforte, Antonella" sort="D Arminio Monforte, Antonella" uniqKey="D Arminio Monforte A" first="Antonella" last="D'Arminio Monforte">Antonella D'Arminio Monforte</name>
<affiliation wicri:level="3"><nlm:aff id="AF0008_19516">Department of Health Sciences, San Paolo University Hospital, Infectious Diseases Unit, Milan, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Health Sciences, San Paolo University Hospital, Infectious Diseases Unit, Milan</wicri:regionArea>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rickenbach, Martin" sort="Rickenbach, Martin" uniqKey="Rickenbach M" first="Martin" last="Rickenbach">Martin Rickenbach</name>
<affiliation wicri:level="3"><nlm:aff id="AF0009_19516">Institute of Social and Preventive Medicine, University of Lausanne, Swiss Cohort Study, Lausanne, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Institute of Social and Preventive Medicine, University of Lausanne, Swiss Cohort Study, Lausanne</wicri:regionArea>
<placeName><settlement type="city">Lausanne</settlement>
<region nuts="3" type="region">Canton de Vaud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Law, Matthew" sort="Law, Matthew" uniqKey="Law M" first="Matthew" last="Law">Matthew Law</name>
<affiliation wicri:level="3"><nlm:aff id="AF0010_19516">The Kirby Institute, University of New South Wales, Sydney, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The Kirby Institute, University of New South Wales, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lundgren, Jens" sort="Lundgren, Jens" uniqKey="Lundgren J" first="Jens" last="Lundgren">Jens Lundgren</name>
<affiliation wicri:level="3"><nlm:aff id="AF0001_19516">CHIP Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>CHIP Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen</wicri:regionArea>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sabin, Caroline" sort="Sabin, Caroline" uniqKey="Sabin C" first="Caroline" last="Sabin">Caroline Sabin</name>
<affiliation wicri:level="4"><nlm:aff id="AF0003_19516">Research Department of Infection and Population Health, University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Research Department of Infection and Population Health, University College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of the International AIDS Society</title>
<idno type="eISSN">1758-2652</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="st1_19516"><title>Introduction</title>
<p>There is a lack of data on potential gender differences in the use of interventions to prevent and treat cardiovascular disease (CVD) in HIV-positive individuals. We investigated whether such differences exist in the D:A:D study.</p>
</sec>
<sec id="st2_19516"><title>Materials and Methods</title>
<p>Follow-up was from 01/02/99 until the earliest of death, 6 months after last visit or 01/02/13. Rates of initiation of lipid-lowering drugs (LLDs), angiotensin-converting enzyme inhibitors (ACEIs), anti-hypertensives and receipt of invasive cardiovascular procedures (ICPs; bypass, angioplasty, endarterectomy) were calculated in those without a myocardial infarction (MI) or stroke at baseline, overall and in groups known to be at higher CVD risk: (i) age >50, (ii) total cholesterol >6.2 mmol/l, (iii) triglyceride >2.3 mmol/l, (iv) hypertension, (v) previous MI, (vi) diabetes, or (vii) predicted 10-year CVD risk >10%. Poisson regression was used to assess whether rates of initiation were higher in men than women, after adjustment for these factors.</p>
</sec>
<sec id="st3_19516"><title>Results</title>
<p>At enrolment, women (<italic>n</italic>
=13,039; median (interquartile range) 34 (29–40) years) were younger than men (<italic>n</italic>
=36,664, 39 (33–46) years, <italic>p</italic>
=0.001), and were less likely to be current smokers (29% vs. 39%, <italic>p</italic>
=0.0001), to have diabetes (2% vs. 3%, <italic>p</italic>
=0.0001) or to have hypertension (7% vs. 11%, <italic>p</italic>
=0.0001). Of 49,071 individuals without a MI/stroke at enrolment, 0.6% women vs. 2.1% men experienced a MI while 0.8% vs. 1.3% experienced a stroke. Overall, women received ICPs at a rate of 0.07/100 person-years (PYRS) compared to 0.29/100 PYRS in men. Similarly, the rates of initiation of LLDs (1.28 vs. 2.46), anti-hypertensives (1.11 vs. 1.38) and ACEIs (0.82 vs. 1.37) were all significantly lower in women than men (<xref ref-type="table" rid="T0001_19516">Table 1</xref>
). As expected, initiation rates of each intervention were higher in the groups determined to be at moderate/high CVD risk; however, within each high-risk group, initiation rates of most interventions (with the exception of anti-hypertensives) were generally lower in women than men. These gender differences persisted after adjustment for potential confounders (<xref ref-type="table" rid="T0001_19516">Table 1</xref>
). </p>
</sec>
<sec id="st4_19516"><title>Conclusion</title>
<p>Use of most CVD interventions was lower among women than men in the D:A:D study. Our findings suggest that actions should be taken to ensure that both men and women are monitored for CVD and, if eligible, receive appropriate CVD interventions.</p>
</sec>
</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>Belgique</li>
<li>Danemark</li>
<li>France</li>
<li>Italie</li>
<li>Pays-Bas</li>
<li>Royaume-Uni</li>
<li>Suisse</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>Aquitaine</li>
<li>Canton de Vaud</li>
<li>Grand Londres</li>
<li>Hollande-Septentrionale</li>
<li>Hovedstaden</li>
<li>Lombardie</li>
<li>Nouvelle-Aquitaine</li>
<li>Nouvelle-Galles du Sud</li>
<li>Provence-Alpes-Côte d'Azur</li>
<li>Région de Bruxelles-Capitale</li>
<li>État de New York</li>
</region>
<settlement><li>Amsterdam</li>
<li>Bordeaux</li>
<li>Bruxelles</li>
<li>Copenhague</li>
<li>Lausanne</li>
<li>Londres</li>
<li>Milan</li>
<li>New York</li>
<li>Nice</li>
<li>Sydney</li>
</settlement>
<orgName><li>University College de Londres</li>
<li>Université Columbia</li>
<li>Université d'Amsterdam</li>
</orgName>
</list>
<tree><country name="Danemark"><region name="Hovedstaden"><name sortKey="Hatleberg, Camilla Ingrid" sort="Hatleberg, Camilla Ingrid" uniqKey="Hatleberg C" first="Camilla Ingrid" last="Hatleberg">Camilla Ingrid Hatleberg</name>
</region>
<name sortKey="Lundgren, Jens" sort="Lundgren, Jens" uniqKey="Lundgren J" first="Jens" last="Lundgren">Jens Lundgren</name>
<name sortKey="Ryom, Lene" sort="Ryom, Lene" uniqKey="Ryom L" first="Lene" last="Ryom">Lene Ryom</name>
</country>
<country name="États-Unis"><region name="État de New York"><name sortKey="El Sadr, Wafaa" sort="El Sadr, Wafaa" uniqKey="El Sadr W" first="Wafaa" last="El-Sadr">Wafaa El-Sadr</name>
</region>
</country>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Mocroft, Amanda" sort="Mocroft, Amanda" uniqKey="Mocroft A" first="Amanda" last="Mocroft">Amanda Mocroft</name>
</region>
<name sortKey="Sabin, Caroline" sort="Sabin, Caroline" uniqKey="Sabin C" first="Caroline" last="Sabin">Caroline Sabin</name>
</country>
<country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Reiss, Peter" sort="Reiss, Peter" uniqKey="Reiss P" first="Peter" last="Reiss">Peter Reiss</name>
</region>
</country>
<country name="Belgique"><region name="Région de Bruxelles-Capitale"><name sortKey="De Wit, Stephan" sort="De Wit, Stephan" uniqKey="De Wit S" first="Stephan" last="De Wit">Stephan De Wit</name>
</region>
</country>
<country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Dabis, Francois" sort="Dabis, Francois" uniqKey="Dabis F" first="Francois" last="Dabis">Francois Dabis</name>
</region>
<name sortKey="Pradier, Christian" sort="Pradier, Christian" uniqKey="Pradier C" first="Christian" last="Pradier">Christian Pradier</name>
</country>
<country name="Italie"><region name="Lombardie"><name sortKey="D Arminio Monforte, Antonella" sort="D Arminio Monforte, Antonella" uniqKey="D Arminio Monforte A" first="Antonella" last="D'Arminio Monforte">Antonella D'Arminio Monforte</name>
</region>
</country>
<country name="Suisse"><region name="Canton de Vaud"><name sortKey="Rickenbach, Martin" sort="Rickenbach, Martin" uniqKey="Rickenbach M" first="Martin" last="Rickenbach">Martin Rickenbach</name>
</region>
</country>
<country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Law, Matthew" sort="Law, Matthew" uniqKey="Law M" first="Matthew" last="Law">Matthew Law</name>
</region>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003925 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003925 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Asie |area= AustralieFrV1 |flux= Main |étape= Exploration |type= RBID |clé= PMC:4224835 |texte= Gender differences in HIV-positive persons in use of cardiovascular disease-related interventions: D:A:D study }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:25394025" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a AustralieFrV1
This area was generated with Dilib version V0.6.33. |